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June 7, 2026Cardiovascular TherapeuticsOpen Access

OAC use in NVAF patients undergoing PCI is linked to ~57% higher persistent AF rates.

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Why the study?

Antithrombotic therapy in patients with nonvalvular AF undergoing PCI is clinically challenging, with real-world strategies often remaining inconsistent.

What are the real-world antithrombotic management strategies in Chinese patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention?

Population

1306 patients with nonvalvular AF undergoing PCI across 36 centers in Shanghai

Comparison

Antithrombotic therapy strategies including DAPT and OACs

Design

Multicenter cross-sectional study

Key result

In Chinese patients with NVAF undergoing PCI, oral anticoagulants were underutilized, with OAC recipients having higher rates of persistent AF than non-recipients (53.2% vs 33.9%, P<0.001).

Authors

JYJiwei YuRuijin HospitalSLShuolin LiuRuijin HospitalRDRun DuInterventional Cardiology

Discussion

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Overview

Highlights OAC underuse in Chinese NVAF-PCI patients; leaves open whether interventions can improve guideline adherence.

Key Points

  • This research examines the antithrombotic management practices for patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention in Shanghai, China.
  • Cross-sectional analysis of data from the Shanghai Cardiac Intervention Quality Control Center, focusing on 1306 NVAF patients.
  • Evaluation of antithrombotic regimens, including dual antiplatelet therapy and oral anticoagulants.
  • Comparison of demographic and clinical characteristics across different antithrombotic strategy groups.
  • Dual antiplatelet therapy was the most common regimen, used by 44.7% of enrolled patients.
  • Only 55.8% of male and 55.6% of female patients with elevated CHA2DS2-VASc scores received anticoagulation therapy.
  • Patients on oral anticoagulants had significantly higher rates of persistent AF (53.2% vs. 33.9%, p < 0.001).

Study Design

Type

Cross-Sectional (n=1,306)

Multicenter

Yes

Structured PICO

What are the real-world antithrombotic management strategies in Chinese patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention?

P
Population
1,306 patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention in 2020 across 36 centers in Shanghai.
E
Exposure
Real-world antithrombotic therapy strategies (including dual antiplatelet therapy [DAPT] and oral anticoagulants [OACs])
O
Outcome
Proportion of patients receiving different antithrombotic regimens (e.g., DAPT, OACs)

Main Result

Absolute Event Rate: 53.2% vs 33.9%

p-value: p=<0.001

There is a substantial gap between guideline recommendations and real-world practice in Chinese AF patients undergoing PCI, characterized by an overreliance on DAPT and underutilization of oral anticoagulants.

Cite This Study

Yu et al. (2026) conducted a cross-sectional in Nonvalvular atrial fibrillation (NVAF) undergoing percutaneous coronary intervention (PCI) (n=1,306). Oral anticoagulants (OACs) vs. No OAC therapy was evaluated on Persistent atrial fibrillation (p=<0.001). In Chinese patients with NVAF undergoing PCI, oral anticoagulants were underutilized, with OAC recipients having higher rates of persistent AF than non-recipients (53.2% vs 33.9%, P<0.001).

synapsesocial.com/papers/6a250c3b7def13d035e1c4a9https://doi.org/10.1155/cdr/5163410
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