Key result
HCM linked to ~11% lower global work efficiency and increased wasted work versus healthy controls.
Why the study?
This study aimed to investigate the value of left ventricular pressure-strain loops in evaluating global and regional myocardial work in patients with hypertrophic cardiomyopathy.
Does left ventricular pressure-strain loop (PSL) echocardiography identify impaired global and regional myocardial work in patients with hypertrophic cardiomyopathy and preserved LVEF compared to healthy controls?
Cross-Sectional (n=65)
No
Does left ventricular pressure-strain loop (PSL) echocardiography identify impaired global and regional myocardial work in patients with hypertrophic cardiomyopathy and preserved LVEF compared to healthy controls?
Absolute Event Rate: 84% vs 95%
p-value: p=<0.001
Left ventricular pressure-strain loop echocardiography can detect impaired global and regional myocardial work in patients with hypertrophic cardiomyopathy even when left ventricular ejection fraction is preserved.
May identify subclinical myocardial impairment in preserved-LVEF HCM; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVE: This study aimed to investigate the value of left ventricular (LV) press-strain loop (PSL) in evaluating global and regional myocardial work (MW) in hypertrophic cardiomyopathy (HCM) patients. METHODS: A total of 30 HCM patients with interventricular septum hypertrophy (HCM group) and 35 healthy subjects (control group) were selected from First Hospital of Qinhuangdao. The general clinical data and conventional ultrasound parameters of two groups were acquired. The MW parameters were analyzed using LV PSL. The regional MW parameters in the HCM group were compared between ventricular septum and the free walls of left ventricle. RESULTS: The epicardial adipose tissue thickness of the HCM group was significantly greater than that of the control group (P < 0.05). Global work efficiency was significantly reduced, while global wasted work was increased in patients with HCM compared with controls (all P < 0.05). The HCM group was compared in the group, to be specific, in the HCM group, the work index, the work efficiency, and the longitudinal strain on the interventricular septum were lower than those on the free wall (all P < 0.05). CONCLUSION: PSL is more effective than LVEF in assessing left ventricular systolic function in HCM and is able to quantify regional myocardial work in the ventricular septum in HCM patients with preserved LVEF, suggesting a novel idea for clinical diagnosis and assessment.
No takes yet. Share an insight, caveat, or question.
Xiao et al. (2023) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=65). Hypertrophic cardiomyopathy vs. Healthy controls was evaluated on Global work efficiency (GWE) (p=<0.001). Patients with hypertrophic cardiomyopathy had significantly reduced global work efficiency (84% vs 95%, p<0.001) and increased global wasted work compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: