Key result
Mitochondrial respiration in peripheral blood mononuclear cells of PAH patients negatively correlated with pulmonary vascular resistance and positively correlated with cardiac index.
Why the study?
Mitochondrial and immune cell dysfunction contributes to pulmonary arterial hypertension development, prompting investigation into PBMC mitochondrial respiration and gene expression.
Population
Patients with idiopathic and hereditary PAH and healthy controls
Comparison
Outpatient PAH patients vs healthy controls, and inpatient PAH hemodynamic parameters
Authors
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PBMC mitochondrial respiration was associated with PAH severity; hypothesis-generating for its role as a noninvasive biomarker.
Observational
Mitochondrial function in the peripheral blood mononuclear cells of PAH patients correlates with disease severity, specifically pulmonary vascular resistance and cardiac index.
Sommer et al. (2022) conducted an observational in Pulmonary Arterial Hypertension. Mitochondrial respiration in PBMC vs. Healthy controls was evaluated on Mitochondrial respiration and its correlation with disease parameters. Mitochondrial respiration in peripheral blood mononuclear cells of PAH patients negatively correlated with pulmonary vascular resistance and positively correlated with cardiac index.
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