Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 10, 2024Antioxidants and Redox SignalingOpen Access

Alterations in Mitochondrial Function in Pulmonary Vascular Diseases

View Full Paper
Ask AI
Bookmark
Share

Why the study?

There was little knowledge of arginine metabolism and mitochondrial functions across different pulmonary hypertension groups.

Population

PH patients and healthy controls from the Pulmonary Vascular Disease Phenomics Program cohort

Comparison

Different PH groups vs healthy controls

Design

Cohort study

Follow-up

At least 4 years

Authors

SFSamar FarhaKAKewal AsosinghPHPaul M. Hassoun

Discussion

Loading...

Member takes

Overview

Mitochondrial and arginine changes may differ by PH group; leaves open targeted interventions pending prospective trials.

Structured PICO

P
Population
Pulmonary hypertension (PH) patients across different clinical groups and healthy controls from the Pulmonary Vascular Disease Phenomics Program cohort
C
Comparator
Healthy controls and other PH groups
O
Outcome
Mitochondrial transmembrane potential, superoxide production, and mass measured in fresh platelets, and global arginine bioavailabilitysurrogate

Group 1 pulmonary arterial hypertension is characterized by a distinct mitochondrial phenotype in platelets that correlates with clinical outcomes like transplant-free survival.

Cite This Study

Farha et al. (2024) studied this question.

synapsesocial.com/papers/6a7ccc76f108d7d7faba4ea3https://doi.org/10.1089/ars.2024.0557
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial dysfunction in pulmonary arterial hypertension2022 · 33 citations
  2. 2Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension2022 · 40 citations
  3. 3Mitochondrial Respiration in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Pulmonary Arterial Hypertension2022 · 12 citations
  4. 4Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity2017 · 60 citations
  5. 5Multidimensional study on mitochondrial dysfunction in pulmonary hypertension2025