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March 8, 2017JCI InsightOpen Access

Platelets from PH patients had significantly greater maximal uncoupled respiration (227.2 ± 11.6 vs 131.1 ± 10.2 pmol O2/min, P < 0.0001) and reserve capacity (124.6 ± 11.1 vs 42.1 ± 8.66 pmol O2/min, P < 0.0001) compared to controls.

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Why the study?

Do platelets from patients with pulmonary hypertension exhibit altered bioenergetics compared to healthy controls?

Population

56 subjects, comprising 28 patients with WHO Group 1 pulmonary hypertension and 28 healthy age- and…

Design

Case-control

Authors

QNQuyen Le NguyenCCCatherine CoreyPWPamela White

Discussion

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Overview

Suggests platelet bioenergetics may serve as a biomarker for pulmonary hypertension severity; leaves.

Structured PICO

Do platelets from patients with pulmonary hypertension exhibit altered bioenergetics compared to healthy controls?

P
Population
56 subjects, comprising 28 patients with WHO Group 1 pulmonary hypertension (mean age 54, 86.4% female) and 28 healthy age- and sex-matched controls (mean age 47, 70.8% female).
C
Comparator
Healthy age and sex-matched controls
O
Outcome
Platelet bioenergetics, specifically oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) to determine glycolytic rates and respiratory reserve capacitysurrogate

Platelets from pulmonary hypertension patients exhibit increased glycolysis and enhanced respiratory reserve capacity driven by fatty acid oxidation, which correlates with hemodynamic severity.

Limitations

  • Small sample size of subgroups on medication
  • Did not assess correlation with brain natriuretic peptide (BNP) levels
  • Cohort represents compensated disease, which may not reflect mitochondrial changes in advanced or decompensated PH

Cite This Study

Nguyen et al. (2017) studied this question.

synapsesocial.com/papers/6a7fac93c32ce294b5d76e5ahttps://doi.org/10.1172/jci.insight.91415
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients2019 · 25 citations
  2. 2Alterations in Mitochondrial Function in Pulmonary Vascular Diseases2024 · 4 citations
  3. 3Mitochondrial Respiration in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Pulmonary Arterial Hypertension2022 · 12 citations
  4. 4The Basic Science of Metabolism in Pulmonary Arterial Hypertension2018 · 10 citations
  5. 5An explorative metabolomic analysis of the endothelium in pulmonary hypertension2022 · 17 citations