Key result
PCOS is linked to elevated resistin, galectin-3, and apelin correlating with HOMA-IR and oxidative stress.
Why the study?
The integrated role of adipokines in linking metabolic and hormonal dysfunction in women with polycystic ovary syndrome remains incompletely understood.
Are adipokine levels and oxidative stress markers altered in women with PCOS compared to controls, and do they correlate with insulin resistance?
Case-Control (n=140)
Are adipokine levels and oxidative stress markers altered in women with PCOS compared to controls, and do they correlate with insulin resistance?
Women with PCOS exhibit altered adipokine levels and oxidative stress indices that correlate with insulin resistance, reflecting underlying metabolic dysfunction.
Elevated adipokines in PCOS may aid metabolic phenotyping; leaves open causality and clinical utility pending prospective data.
BACKGROUND: Although polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder among reproductive-aged women, the integrated role of adipokines in linking metabolic and hormonal dysfunction remains incompletely understood. OBJECTIVE: The study aims to evaluate the associations between lipid profile alterations, selected adipokines (resistin, galectin-3, and apelin), oxidative stress markers, and the insulin resistance index (HOMA-IR) in women with PCOS compared to controls. METHODS: This case-control study included 85 women with PCOS and 55 age-matched controls. Anthropometric and clinical data were collected. Levels of lipid profiles, adipokines, oxidative stress markers, and HOMA-IR were measured. Group comparisons and correlation analyses were performed. RESULTS: Women with PCOS demonstrated elevated levels of resistin, galectin-3, and apelin compared to the controls, with respective measurements of 3.55 ± 0.52 vs 1.07 ± 0.34, 10.01 ± 1.76 vs 3.49 ± 1.03, and 289.23 ± 20.08 vs 191.31 ± 31.30), respectively. MDA exhibited a significant increase, whereas TAC was significantly reduced in the PCOS group. HOMA-IR showed significant positive associations with lipid profiles, adipokines, and levels of MDA, and an inverse correlation with HDL and TAC. CONCLUSION: The findings support the concept that altered adipokine levels and oxidative stress indices may reflect underlying metabolic dysfunction in women with PCOS.
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Saleem et al. (2026) conducted a case-control in Polycystic ovary syndrome (n=140). Polycystic ovary syndrome vs. Age-matched controls was evaluated on Associations between lipid profile alterations, selected adipokines, oxidative stress markers, and HOMA-IR. Women with PCOS had elevated levels of resistin (3.55 vs 1.07), galectin-3 (10.01 vs 3.49), and apelin (289.23 vs 191.31) compared to controls, correlating with HOMA-IR and oxidative stress.
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