⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

June 8, 2026Journal of Medicinal Chemistry

Synthesis and Preclinical Evaluation of Structurally Optimized ⁶⁸ Ga-Labeled CXCR4 Radiotracers for PET Imaging of Atherosclerotic Plaque Inflammation

Jinglin Zhang Na Wang Y Y Y S Li Yixiang Lin Kunyao Wang Wenqi Zhao Fengming Liu Feng Gao

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to evaluate Ga-SDNUM11 as a radiotracer for imaging atherosclerotic plaque inflammation.
Synthesis of Ga-SDNUM11 with structural optimization.
Preclinical evaluation for PET imaging efficacy.
Focus on targeting CXCR4 in inflamed atherosclerotic plaques.
Ga-SDNUM11 demonstrated effective localization to atherosclerotic plaques.
Potential for enhanced cardiovascular risk stratification through improved imaging.
Supported by increased specific binding to CXCR4-expressing cells.

Implication

Preclinical evaluation of Ga-SDNUM11 targets inflammation in atherosclerotic plaque, indicating potential for cardiovascular risk assessment.

Abstract

Ga]Ga-SDNUM11 as a promising CXCR4-targeted radiotracer for PET imaging of atherosclerotic plaque inflammation and cardiovascular risk stratification.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2900ff6f82f25be989d778 https://doi.org/10.1021/acs.jmedchem.6c00652

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Synthesis and Evaluation of Novel C-X-C Chemokine Receptor 4-Targeted Radiotracers for Oncological Imaging2025 · 4 citations
2Imaging Inflammation in Atherosclerosis with CXCR4-Directed <sup>68</sup>Ga-Pentixafor PET/CT: Correlation with <sup>18</sup>F-FDG PET/CTcohort · 2019 · 70 citations
3Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma2024 · 5 citations
4Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer <sup>68</sup>Ga-Pentixafor for PETpreclinical · 2016 · 112 citations
5Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque Using <sup>68</sup>Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burdencohort · 2017 · 121 citations