Key result
High-dose L-carnitine treatment significantly improved cardiac performance and restored total high-energy phosphate stores in Syrian hamsters with dilated or hypertrophic cardiomyopathy.
Why the study?
Does L-carnitine improve cardiac performance and restore high-energy phosphate pools in cardiomyopathic Syrian hamsters?
Population
Syrian hamsters with either dilated or hypertrophic cardiomyopathy, and an inbred control strain
Comparison
L-carnitine 1 g/kg/day intraperitoneally for 6… vs Sham treatment
Design
Preclinical
Follow-up
6 months
Authors
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Hypothesis-generating in hamster models; does not support clinical use pending human trials.
Does L-carnitine improve cardiac performance and restore high-energy phosphate pools in cardiomyopathic Syrian hamsters?
High-dose L-carnitine treatment improves cardiac mechanical performance and restores myocardial high-energy phosphate stores in hamster models of dilated and hypertrophic cardiomyopathy.
J T Whitmer (1987) studied Dilated or hypertrophic cardiomyopathy. L-carnitine vs. Sham treatment was evaluated on Cardiac performance and high-energy phosphate stores. High-dose L-carnitine treatment significantly improved cardiac performance and restored total high-energy phosphate stores in Syrian hamsters with dilated or hypertrophic cardiomyopathy.
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