Why the study?
Epicardial adipose tissue contributes to coronary artery disease pathogenesis through pro-inflammatory adipokines, and ANGPTL4 plays a critical role in atherosclerosis progression, prompting investigation of its expression in epicardial adipose tissue in patients with CAD.
Is ANGPTL4 expression increased in the epicardial adipose tissue of patients with coronary artery disease?
Is ANGPTL4 expression increased in the epicardial adipose tissue of patients with coronary artery disease?
ANGPTL4 and IL-1β expression are significantly elevated in the epicardial adipose tissue of patients with coronary artery disease, suggesting a potential role in the progression of atherosclerosis.
Should not change CAD management; leaves open whether ANGPTL4/IL-1β in EAT contributes to atherosclerosis.
Epicardial adipose tissue (EAT) is known to affect atherosclerosis and coronary artery disease (CAD) pathogenesis, persistently releasing pro-inflammatory adipokines that affect the myocardium and coronary arteries. Angiopoietin-like 4 (ANGPTL4) is a protein secreted from adipose tissue and plays a critical role in the progression of atherosclerosis. Here, the expression of ANGPTL4 in EAT was investigated in CAD subjects. Thirty-four consecutive patients (13 patients with significant CAD; 21 patients without CAD) undergoing elective open-heart surgery were recruited. EAT and pericardial fluid were obtained at the time of surgery. mRNA expression and ANGPTL4 and IL-1β levels were evaluated by qRT-PCR and ELISA. The expression of ANGPTL4 (p = 0.0180) and IL-1β (p < 0.0001) in EAT significantly increased in the CAD group compared to that in the non-CAD group and positively correlated (p = 0.004). Multiple regression analysis indicated that CAD is a contributing factor for ANGPTL4 expression in EAT. IL-1β level in the pericardial fluid was significantly increased in patients with CAD (p = 0.020). Moreover, the expression of ANGPTL4 (p = 0.004) and IL-1β (p < 0.001) in EAT was significantly increased in non-obese patients with CAD. In summary, ANGPTL4 expression in EAT was increased in CAD patients.
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Katanasaka et al. (2022) studied this question.
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