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June 11, 2026Current Bioactive Compounds

Resveratrol Attenuates Cognitive Impairments, Oxidative Damage,and Neuroinflammation in a Rat Model of Imidacloprid-inducedNeurodegeneration

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Authors

SKShivangi KumariHPHarshit PalDSDipti Srivastava

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Overview

Randomized trial evaluates resveratrol's protective effects against imidacloprid-induced neurotoxicity, suggesting a potential treatment option.

Key Points

  • This research aims to evaluate resveratrol's effectiveness in counteracting imidacloprid-induced neurotoxicity.
  • Conducted a systematic literature review of studies from 2000 to 2024.
  • Albino Wistar rats were divided into five groups with different treatments over 28 days.
  • Behavioral tests and biochemical assays were utilized to assess neuroprotective effects.
  • Imidacloprid exposure resulted in behavioral impairments and increased oxidative stress markers.
  • Resveratrol treatment improved memory function, reduced inflammation, and restored antioxidant levels.
  • Histopathological analysis revealed less neuronal damage in the resveratrol group compared to the imidacloprid group.

Cite This Study

Kumari et al. (2026) studied this question.

synapsesocial.com/papers/6a2a512e80c8f91e7f39d780https://doi.org/10.2174/0115734072423542260220023901
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol2024
  2. 2Resveratrol Mitigates Imidacloprid‐Induced Neurotoxicity, Intestinal Dysfunction and Other Stresses in Newly Emerged Bees ( <i>Apis mellifera</i> )2026 · 1 citations
  3. 3Recovery Effects of Resveratrol and Berberine Against Inflammation, Oxidative Stress, Biochemical, and Pathological Damage in Rats with Imidacloprid-Induced Hepatorenal Toxicity2026
  4. 4Neurobehavioral Toxicity of Acetamiprid in Male Rats and the Protective Role of Resveratrol: The Involvement of the PI3K/Akt/BDNF Pathway2026 · 1 citations
  5. 5Berberine chloride loaded nano‐<scp>PEGylated</scp> liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting <scp>NLRP3</scp>/Caspase‐1/<scp>GSDMD</scp>‐mediated pyroptosis2024 · 3 citations