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June 11, 2026Journal of Biochemical and Molecular Toxicology

Neurobehavioral Toxicity of Acetamiprid in Male Rats and the Protective Role of Resveratrol: The Involvement of the PI3K/Akt/BDNF Pathway

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Authors

MHM. HassanAMAshraf M. MorganMIMarwa A. Ibrahim

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Overview

Randomized trial investigates neurobehavioral toxicity in male rats, suggesting Resveratrol mitigates damage.

Key Points

  • This research aims to explore the neurobehavioral toxicity of Acetamiprid and the protective role of Resveratrol.
  • Divided 40 male rats into four groups: Control, ACP 25 mg/kg, RSV 20 mg/kg, and ACP + RSV, treated for 90 days.
  • Conducted behavioral tests, biochemical analyses for oxidative stress and inflammatory markers, and gene expression profiling.
  • Performed histopathological examinations and Tau immunostaining to assess brain changes.
  • Acetamiprid exposure significantly increased anxiety-like behavior and cognitive impairment.
  • The ACP group displayed increased oxidative stress markers, apoptosis, and inflammation (GSH, CAT, MDA, TNF-α).
  • Co-treatment with Resveratrol improved neurobehavioral functions and reduced cellular injury.

Cite This Study

Hassan et al. (2026) studied this question.

synapsesocial.com/papers/6a2a517c80c8f91e7f39dc35https://doi.org/10.1002/jbt.70958
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