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March 18, 2026Environmental ToxicologyOpen Access

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

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Authors

SDSelim DemirNANihal Türkmen AlemdarEYEsin Yuluğ

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Overview

Animal study demonstrates chrysin's protective effects on testicular injury in mice, indicating potential therapeutic uses.

Key Points

  • To evaluate the protective effects of chrysin against acetamiprid-induced testicular injury in male mice.
  • Used male Balb/c mice for experimentation
  • Administered acetamiprid and chrysin via intragastric route over 14 days
  • Measured levels of oxidative stress, inflammation, testosterone, and inhibin B
  • Conducted TUNEL assay for apoptosis detection
  • Chrysin significantly improved oxidative stress and inflammation levels
  • Reversed declines in serum testosterone and inhibin B levels due to acetamiprid
  • Reduced TUNEL (+) cell count indicating decreased apoptosis
  • Prevented the decline in sperm count and viability, reducing abnormal sperm
  • Improved degenerative testicular findings at a dose of 20 mg/kg chrysin

Cite This Study

Demir et al. (2026) studied this question.

synapsesocial.com/papers/69ba425c4e9516ffd37a2894https://doi.org/10.1002/tox.70076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulatory Effects of Chrysin on Cadmium‐Induced Hepatotoxicity and Testicular Injury in Rats2026 · 1 citations
  2. 2Protective Role of Chrysin against Mercury Chloride-Induced Testicular Damage via Oxidative Stress, Inflammation, Apoptosis, Endoplasmic Reticulum Stress, and Autophagy Pathways2026
  3. 3Protective effect of Chlorella vulgaris on sub-chronic hepatic and testicular toxicity induced by acetamiprid in rats2026 · 1 citations
  4. 4Effect of Chrysin and Chrysin Nanocrystals on Chlorpyrifos-Induced Dysfunction of the Hypothalamic-Pituitary-Testicular Axis in Rats2024 · 6 citations
  5. 5Nano‐Rosmarinic Acid Protects Against Chlorfenapyr‐Induced Testicular Toxicity Through Modulation of NRF2/HO‐1 and NF‐κB/NLRP3 Signaling Pathways2026 · 1 citations