Key result
Real-time IVUS guides subintimal wire repositioning to enable safe DES deployment after IVL-induced dissection.
Why the study?
Intravascular lithotripsy-induced coronary dissection may lead to inadvertent guidewire migration into the subintimal space, where real-time IVUS is essential to identify wire position and guide safe stent deployment.
Case Report (n=1)
Real-time IVUS can guide the safe redirection of a subintimal guidewire into the true lumen via balloon inflation during complex PCI complicated by IVL-induced dissection.
IVUS may enable safe stenting after IVL-induced subintimal wire migration; leaves open standardized protocols pending larger series.
Background Intravascular lithotripsy (IVL) is an effective modality for modifying severely calcified coronary lesions; however, IVL-induced coronary dissection may occasionally lead to inadvertent guidewire migration into the subintimal space. In such complex scenarios, real-time intravascular ultrasound (IVUS) is essential for identifying wire position, understanding dynamic wire–vessel interactions, and guiding safe stent deployment. Case Summary An 80-year-old woman with unstable angina underwent percutaneous coronary intervention for a severely calcified and tortuous left anterior descending artery. IVL was performed for calcium modification, but a longitudinal medial dissection flap developed, and the guidewire migrated into the subintimal space due to tortuosity-related wire bias. Multiple rewiring attempts using a double-lumen catheter and balloon support were unsuccessful. Real-time IVUS was used to evaluate the behaviour of a semi-compliant balloon positioned on the subintimal wire. IVUS demonstrated that balloon inflation redirected both the balloon and wire from the subintimal space into the true lumen, facilitated by anchoring of proximal and distal wire segments that remained within the true lumen. This confirmation enabled safe and accurate deployment of a drug-eluting stent in the true lumen. Discussion Even when a guidewire migrates into the subintimal space during IVL-induced coronary dissection, balloon inflation may dynamically shift the device toward the true lumen due to anchoring by wire segments located proximally and distally within unaffected vessel segments. Real-time IVUS is indispensable for visualising this dynamic behaviour and confirming whether balloon or stent expansion occurs within the true lumen. This IVUS-guided strategy may be valuable when conventional rewiring techniques fail.
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Hideo Tokuyama (2026) conducted a case report in Unstable angina with severely calcified coronary lesions and IVL-induced dissection (n=1). Real-time IVUS-guided balloon inflation for wire repositioning was evaluated on Safe and accurate deployment of a drug-eluting stent in the true lumen. Real-time IVUS successfully guided the repositioning of a subintimal guidewire into the true lumen via balloon inflation, enabling safe drug-eluting stent deployment after IVL-induced dissection.
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