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June 11, 2026Nano ResearchOpen Access

Nanozyme-mediated delivery of natural compounds induces ferroptosis to potentiate radiotherapy in bladder cancer

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Authors

LLLingyun LiuXFXiaofei FuMLMeng Lyu

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Overview

Randomized trial shows enhanced immune response and tumor inhibition in bladder cancer using ferroptosis and radiotherapy, suggesting a novel treatment strategy.

Key Points

  • This study aims to enhance radiotherapy effectiveness in bladder cancer by utilizing nanozyme-mediated delivery of baicalin to induce ferroptosis.
  • Developed a ruthenium-incorporated ZIF-8 nanostructure loaded with baicalin and coated with hyaluronic acid.
  • Evaluated tumor homing through CD44 targeting and intracellular activity for oxygen and reactive oxygen species generation.
  • Combined nanozyme treatment with ionizing radiation to assess the impact on tumor growth and systemic immune response.
  • Nanozyme significantly improved local radiation energy deposition, enhancing therapeutic outcomes at tumor sites.
  • Combination treatment led to a potent systemic immune response that inhibited primary tumor progression and metastasis.
  • Hyaluronic acid functionalization ensured effective targeting and drug delivery to bladder cancer tissue.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52d980c8f91e7f39eb05https://doi.org/10.26599/nr.2026.94908904
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual‐Immunotherapy Against Bladder Cancer2026
  2. 2NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer2025
  3. 3Light-Triggered Nanozymes Remodel the Tumor Hypoxic and Immunosuppressive Microenvironment for Ferroptosis-Enhanced Antitumor Immunity2024 · 153 citations
  4. 4Dual-Regulated Nanodrug Potentiates Immunotherapy by Synergizing Ferroptosis with Radiotherapy to Reverse the Immunosuppressive Tumor Microenvironment2025
  5. 5Abstract 5762: Engineering cell membrane nanoparticlesenhance immunotherapy and radiodynamic therapy for lung adenocarcinoma by promoting cGAS-STING and ferroptosis2024