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March 22, 2026Advanced ScienceOpen Access

Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual‐Immunotherapy Against Bladder Cancer

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Authors

XXXiaojian XuRLRui LiangAZAnguo Zhao

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Overview

Demonstrates dual-immunotherapy triggers tumor cell death in bladder cancer, implying innovative therapeutic strategies.

Key Points

  • This research investigates the combined effects of fenbendazole and photothermal therapy on bladder cancer via ferroptosis induction.
  • Developed a nanoplatform integrating fenbendazole, bovine serum albumin, and polydopamine.
  • Administered the treatment via transurethral intravesical delivery in a mouse model.
  • Assessed drug release, tumor cell death mechanisms, and immune response induction.
  • Induced significant lipid peroxidation and mitochondrial dysfunction in bladder cancer cells.
  • Promoted immunogenic cell death markers leading to enhanced dendritic cell maturation.
  • Demonstrated strong anti-tumor efficacy with good biosafety in in vivo models.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69bf8978f665edcd009e9310https://doi.org/10.1002/advs.74876
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Also Consider

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  1. 1Nanozyme-mediated delivery of natural compounds induces ferroptosis to potentiate radiotherapy in bladder cancer2026
  2. 2Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy2025 · 17 citations
  3. 3Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy2025 · 5 citations
  4. 4Cell Membrane‐Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis‐Enhanced Photodynamic Immunotherapy2024 · 19 citations
  5. 5NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer2025