Key result
Primary aldosteronism and essential hypertension were associated with modest elevations in plasma BNP (median 26 and 23 pg/ml vs 14 pg/ml in controls), driven by diastolic BP and LV mass index.
Why the study?
Do essential hypertension and primary aldosteronism increase plasma BNP concentration compared to healthy controls?
Population
120 subjects: 40 patients with moderate to severe essential hypertension, 40 BP-matched patients with…
Comparison
Primary aldosteronism or essential hypertension vs Healthy controls
Design
Cross-sectional
Authors
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Modest BNP elevations in hypertension warrant cautious interpretation; leaves open whether they add diagnostic value beyond diastolic BP and LV mass.
Cross-Sectional (n=120)
Do essential hypertension and primary aldosteronism increase plasma BNP concentration compared to healthy controls?
Absolute Event Rate: 26% vs 14%
p-value: p=0.01
Both primary aldosteronism and essential hypertension are associated with modest elevations in BNP, which are independently determined by diastolic BP and left ventricular mass index rather than specific hyperaldosteronism effects.
Jakubik et al. (2006) conducted a cross-sectional in Essential hypertension and primary aldosteronism (n=120). Primary aldosteronism and essential hypertension vs. Healthy controls was evaluated on Plasma BNP concentration (p=0.01). Primary aldosteronism and essential hypertension were associated with modest elevations in plasma BNP (median 26 and 23 pg/ml vs 14 pg/ml in controls), driven by diastolic BP and LV mass index.
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