Key result
Left ventricular systolic dysfunction in hypertensive patients is linked to significantly higher NT-proBNP levels.
Why the study?
Does the presence of hypertension, left ventricular hypertrophy, or left ventricular systolic dysfunction affect plasma NT-proBNP concentrations?
Population
91 individuals divided into 5 groups: 15 echocardiographic normal controls; 22 patients with hypertension…
Design
Cohort
Authors
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Supports NT-proBNP as specific marker for LV systolic dysfunction amid hypertension; leaves open prospective validation in larger cohorts.
Observational (n=91)
Does the presence of hypertension, left ventricular hypertrophy, or left ventricular systolic dysfunction affect plasma NT-proBNP concentrations?
p-value: p=< 0.0001
NT-proBNP remains a reliable diagnostic marker for left ventricular systolic dysfunction in hypertensive patients, as its levels are not significantly elevated by hypertension or LVH alone.
Suneel Talwar (2000) conducted an observational in Hypertension (n=91). Left ventricular systolic dysfunction vs. Normal left ventricular systolic function was evaluated on Plasma concentration of NT proBNP (p=< 0.0001). Left ventricular systolic dysfunction in hypertensive patients was associated with a significant rise in NT proBNP concentrations compared to patients with normal systolic function (p < 0.0001).