Key result
In patients with primary aldosteronism, plasma BNP levels significantly correlated with SV1 + RV5 voltage (r=0.65, P<0.01) and total blood volume (r=0.57, P<0.01), whereas ANP did not.
Why the study?
Which natriuretic peptide (ANP or BNP) is more closely related to cardiac load and volume retention in patients with primary aldosteronism?
Observational (n=11)
Which natriuretic peptide (ANP or BNP) is more closely related to cardiac load and volume retention in patients with primary aldosteronism?
In patients with primary aldosteronism, BNP serves as a better marker of cardiac load and volume status than ANP.
May support BNP over ANP as marker of cardiac load and volume in primary aldosteronism; leaves open prospective validation before clinical adoption.
BACKGROUND: Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones with natriuretic and vasodilator actions. The present study was carried out to determine the natriuretic peptide that is closely related to cardiac load and volume retention in patients with primary aldosteronism (PA). METHODS: We examined 11 patients with PA due to aldosterone-producing adrenal adenoma before and after surgical resection. Plasma levels of ANP and BNP were measured by specific immunoradiometric assays, and total blood volume was determined by a plasma tracer method with (131)I-human albumin. RESULTS: Plasma levels of ANP and BNP were elevated in the PA patients compared with normotensive control subjects (P < .01), and the elevated ANP and BNP levels were reduced (P < .01) after adenoma resection. When analyzed with the pre- and postoperative data, a significant relationship was observed between mean blood pressure and plasma levels of ANP (r = 0.64, P < .01) and BNP (r = 0.58, P < .01). The BNP was significantly correlated with the SV1 + RV5 voltage (r = 0.65, P < .01) and with total blood volume (r = 0.57, P < .01), but this was not the case for ANP. CONCLUSION: The present results suggest that the plasma level of BNP is more closely related to cardiac load or volume status than ANP is, in patients with PA due to adrenal adenoma.
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Kato et al. (2005) conducted an observational in Primary aldosteronism (n=11). Surgical resection of adrenal adenoma vs. Pre-operative baseline and normotensive controls was evaluated on Correlation of plasma BNP with SV1 + RV5 voltage and total blood volume (r = 0.65 and r = 0.57, p=< .01). In patients with primary aldosteronism, plasma BNP levels significantly correlated with SV1 + RV5 voltage (r=0.65, P<0.01) and total blood volume (r=0.57, P<0.01), whereas ANP did not.
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