Key result
Plasma ANP is elevated in primary aldosteronism and Bartter's syndrome but low in Gordon's syndrome.
Why the study?
Plasma levels of atrial natriuretic peptide in conditions with disturbed volume homeostasis such as primary aldosteronism, Gordon's syndrome, and Bartter's syndrome were not well characterized.
Observational
ANP may mark volume expansion in aldosteronism; leaves open its diagnostic role without larger validation.
Plasma levels of ANP were measured in normal subjects and in three conditions associated with disturbed volume homeostasis. Levels of ANP were appropriately raised in seven patients with primary aldosteronism, and fell to normal following removal of an aldosterone-producing adenoma in six and dexamethasone treatment in one patient with glucocorticoid-suppressible hyperaldosteronism. The level of ANP in one patient with Gordon's syndrome (a condition associated with plasma volume expansion) was lower than in the patients with primary aldosteronism, both before and after saline infusion. This is consistent with reduced ANP responsiveness in this condition. responsiveness in this condition. Levels of ANP were inappropriately elevated in three patients with Bartter's syndrome (a condition with plasma volume contraction) and rose further during saline infusion. This is consistent with primary hypersecretion of ANP.
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Tunny et al. (1986) conducted an observational in Primary aldosteronism, Gordon's syndrome, Bartter's syndrome. Conditions with disturbed volume homeostasis vs. Normal subjects was evaluated on Plasma levels of atrial natriuretic peptide (ANP). Plasma ANP levels were raised in primary aldosteronism, inappropriately elevated in Bartter's syndrome, and relatively low in Gordon's syndrome compared to primary aldosteronism.
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