January 1, 1991Clinical and Experimental Hypertension

Dissociation of Plasma Atrial Natriuretic Peptide Responses to Upright Posture and Furosemide Administration in Patients with Normal-, Low Renin Essential Hypertension and Primary Aldosteronism

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Why the study?

How do plasma ANP levels respond to upright posture and furosemide administration in patients with different types of hypertension?

Structured PICO

How do plasma ANP levels respond to upright posture and furosemide administration in patients with different types of hypertension?

Population

34 patients including normal renin essential hypertension (n=12), low renin essential hypertension (n=11), and primary aldosteronism due to aldosterone producing adenoma (APA, n=8) and idiopathic hyperaldosteronism (IHA, n=3).

Intervention

4 hours upright posture and furosemide administration

Comparator

Overnight rest in the supine position (baseline)

Outcome

Plasma levels of atrial natriuretic peptide (ANP)surrogate

Patients with primary aldosteronism exhibit high basal ANP levels that do not decrease in response to upright posture and furosemide, unlike patients with essential hypertension.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

ANP non-suppression with posture and furosemide may distinguish primary aldosteronism from essential hypertension; hypothesis-generating and should not yet change practice.

Cite This Study

Sergev et al. (1991) studied this question.

synapsesocial.com/papers/6a71547da528af2d65c40686 https://doi.org/10.3109/10641969109045060

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

ANP non-suppression with posture and furosemide may distinguish primary aldosteronism from essential hypertension; hypothesis-generating and should not yet change practice.

Dissociation of Plasma Atrial Natriuretic Peptide Responses to Upright Posture and Furosemide Administration in Patients with Normal-, Low Renin Essential Hypertension and Primary Aldosteronism

Structured PICO

Discussion

Implication

Cite This Study

Topics

Dissociation of Plasma Atrial Natriuretic Peptide Responses to Upright Posture and Furosemide Administration in Patients with Normal-, Low Renin Essential Hypertension and Primary Aldosteronism

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider