Key result
In patients with essential hypertension, the combined stimuli of 60 mg intravenous furosemide and a 2-hour walk increased mean plasma renin activity from 1.47 to 3.17 ng/ml/hr and plasma aldosterone from 8.0 to 17.8 ng/dl.
Why the study?
How do plasma renin activity and plasma aldosterone concentration respond to furosemide and walking stimuli in patients with essential hypertension?
Observational (n=106)
No
How do plasma renin activity and plasma aldosterone concentration respond to furosemide and walking stimuli in patients with essential hypertension?
Absolute Event Rate: 3.17% vs 1.47%
The renin-aldosterone system responsiveness to furosemide and walking decreases with age in essential hypertension, and while aldosterone secretion is mainly governed by the renin-angiotensin system, direct correlation between PRA and PAC is lacking.
No takes yet. Share an insight, caveat, or question.
Supports renin phenotyping in essential hypertension; leaves open age effects and PRA-PAC correlations.
Shun-ichi Hata (1977) conducted an observational in Essential hypertension (n=106). Furosemide injection and walking vs. Recumbent position (baseline) was evaluated on Mean plasma renin activity (PRA) in ng/ml/hr. In patients with essential hypertension, the combined stimuli of 60 mg intravenous furosemide and a 2-hour walk increased mean plasma renin activity from 1.47 to 3.17 ng/ml/hr and plasma aldosterone from 8.0 to 17.8 ng/dl.
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