Key result
Slow intravenous alteplase successfully treats a case of mechanical aortic valve thrombosis presenting as MI.
Why the study?
Mechanical aortic valve thrombosis is a rare complication in patients with mechanical valve replacements requiring lifelong anticoagulation to prevent thrombotic events.
Case Report (n=1)
Slow intravenous alteplase infusion can be a successful treatment strategy for mechanical aortic valve thrombosis presenting with acute coronary occlusion.
Supports thrombolytics as nonsurgical option for mechanical aortic valve thrombosis; extends RCT evidence for this rare condition.
BACKGROUND: Mechanical aortic valve thrombosis is a rare complication in patients with mechanical valve replacements. Despite the advantages of mechanical valves, they necessitate lifelong anticoagulation therapy to prevent thrombotic events. CASE SUMMARY: A 32-year-old man with a mechanical aortic valve presented with chest pain and dyspnea suggestive of myocardial infarction. Left heart catheterization revealed 100% occlusion of the distal left circumflex artery whereas cardiac computed tomography revealed a thrombus on the mechanical aortic valve. The patient was successfully treated with thrombolytic therapy using slow intravenous Alteplase infusion.
No takes yet. Share an insight, caveat, or question.
Munawar et al. (2025) conducted a case report in Mechanical aortic valve thrombosis (n=1). Alteplase was evaluated. Thrombolytic therapy using slow intravenous Alteplase infusion successfully treated a 32-year-old man with mechanical aortic valve thrombosis presenting as myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: