Key result
Female sex was associated with higher levels of FVII:C (134% vs 117%, p<0.0005) and fibrinogen (3.4 vs 3.2 g/l, p=0.01) compared to men in subjects with suspected coronary artery disease.
Why the study?
Do women with coronary artery disease have different levels of circulating haemostatic risk factors compared to men?
Population
609 subjects admitted for coronary angiography for suspected coronary artery disease. A sub-cohort of 296…
Design
Cross-sectional
Authors
Loading...
May contribute to worse CAD prognosis in women; leaves open causal role and need for sex-specific validation.
Observational (n=609)
No
Do women with coronary artery disease have different levels of circulating haemostatic risk factors compared to men?
Absolute Event Rate: 134% vs 117%
p-value: p=< 0.0005
Elevated circulating levels of prothrombotic factors (PAI-1, vWF, fibrinogen, and FVII:C) in women with CAD may contribute to their adverse cardiovascular risk profile and poorer prognosis compared to men.
Ossei‐Gerning et al. (1998) conducted an observational in Coronary artery disease (n=609). Female sex vs. Male sex was evaluated on Factor VII:C (FVII:C) levels (p=< 0.0005). Female sex was associated with higher levels of FVII:C (134% vs 117%, p<0.0005) and fibrinogen (3.4 vs 3.2 g/l, p=0.01) compared to men in subjects with suspected coronary artery disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: