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July 15, 2021BiomoleculesOpen Access

Fibrinogen and a Triad of Thrombosis, Inflammation, and the Renin-Angiotensin System in Premature Coronary Artery Disease in Women: A New Insight into Sex-Related Differences in the Pathogenesis of the Disease

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Key result

Fibrinogen plays a central role in thrombosis, inflammation, and the renin-angiotensin system, contributing more significantly to premature coronary artery disease in women than in men.

Why the study?

Sufficiently powered clinical and experimental studies assessing multipathogenic, sex-related differences in coronary artery disease formation and progression across different age periods are lacking.

Design

Review

Authors

KKKarolina KryczkaInstitute of CardiologyMKMariusz KrukInterventional CardiologyMDMarcin DemkowInstitute of Cardiology

Discussion

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Member takes

Overview

Fibrinogen's greater role in women's premature CAD warrants caution in risk models; leaves open sex-specific prospective trials.

Structured PICO

P
Population
Women with premature coronary artery disease (CAD)

Fibrinogen and its interaction with inflammation and the renin-angiotensin system may drive sex-specific differences in the pathogenesis of premature coronary artery disease in women.

Limitations

  • Many gaps in both experimental and clinical studies on sex-related differences in premature CAD exist.

Cite This Study

Kryczka et al. (2021) conducted a review in Premature Coronary Artery Disease. Fibrinogen vs. Men was evaluated. Fibrinogen plays a central role in thrombosis, inflammation, and the renin-angiotensin system, contributing more significantly to premature coronary artery disease in women than in men.

synapsesocial.com/papers/6a3465ee825819368db4bc31https://doi.org/10.3390/biom11071036
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.1995 · 536 citations
  2. 2Coronary Heart Disease Mortality Among Young Adults in the U.S. From 1980 Through 20022007 · 594 citations
  3. 3Therapeutic interventions to lower plasma fibrinogen concentration1995 · 54 citations
  4. 4European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)2012 · 8,527 citations