Key result
Metabolic therapies show potential benefit in heart failure despite lacking large outcome trials.
Why the study?
To propose that heart failure involves a reactive hyperadrenergic state increasing free fatty acids, impairing glucose metabolism, and causing insulin resistance, outlining therapeutic aims for metabolic therapy.
This review highlights the potential of metabolic therapies to counteract the hyperadrenergic state and lipotoxicity associated with heart failure.
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Metabolic modulation may benefit glucose handling in HF; leaves open confirmation in outcome trials before practice change.
Opie et al. (2009) conducted a review in Heart failure. Metabolic therapy was evaluated. Metabolic therapies targeting the hyperadrenergic state and free fatty acid metabolism offer potential clinical benefits in heart failure, though large outcome trials are lacking.
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