Key result
US mortality for coexisting CAD and HF drops ~39% since 1999 despite persistent disparities.
Why the study?
Coronary artery disease and heart failure frequently coexist, yet national mortality trends capturing both conditions together remain understudied.
Population
2,930,567 U.S. adult deaths with coexisting CAD and HF
Comparison
Mortality trends stratified by demographics, region, and clinical presentation
Design
Retrospective epidemiological analysis of CDC WONDER multiple-cause-of-death data
Authors
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Substantial remaining mortality from coexisting CAD and HF requires vigilant management; leaves open mechanisms behind regional and sex disparities.
Observational (n=2,930,567)
Yes
Absolute Event Rate: 43.7% vs 71.6%
While overall mortality for coexisting CAD and HF in the U.S. declined from 1999 to 2024, significant demographic and geographic disparities persist, highlighting the need for targeted prevention in high-risk populations.
Bhagia et al. (2026) conducted an observational in Coexisting Coronary Artery Disease (CAD) and Heart Failure (HF) (n=2,930,567). Calendar year (1999-2024) vs. 1999 was evaluated on Age-adjusted mortality rate (per 100,000). Age-adjusted mortality for coexisting CAD and HF in U.S. adults declined significantly from 71.6 per 100,000 in 1999 to 43.7 in 2024, with persistent demographic and geographic disparities.
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