What question did this study set out to answer?

To define the immunological landscape and mechanisms driving Epstein-Barr virus-positive diffuse large B-cell lymphoma.

June 12, 2026LeukemiaOpen Access

Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma

View Full Paper

Ask AI

Bookmark

Authors

ÉFÉanna FennellUniversity of Limerick SLSoi Cheng LawThe University of Queensland ADAlexander C. DowellUniversity of Birmingham

Discussion

Member takes

Implication

Randomized trial shows impaired antiviral immune responses in patients with EBV-positive diffuse large B-cell lymphoma, indicating critical immunological changes.

Key Points

To define the immunological landscape and mechanisms driving Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Functional profiling of peripheral antiviral T-cell immunity and spatial proteomics.
In vitro modeling to analyze tumor microenvironment characteristics.
Comparative analysis between EBV⁺DLBCL and other EBV-associated conditions.
Both EBV⁺ and EBV⁻ DLBCL patients showed broad impairments in antiviral T-cell responses compared to healthy controls.
EBV⁺DLBCL exhibited significantly reduced CD8⁺ T-cell densities and a marked immunosuppressive signature associated with macrophages.
Suppressive myeloid niches were enriched around LMP1-expressing tumor cells, a unique feature of EBV⁺DLBCL.

Cite This Study

Fennell et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2f68101cf8926f01c8c https://doi.org/10.1038/s41375-026-02994-3

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial shows impaired antiviral immune responses in patients with EBV-positive diffuse large B-cell lymphoma, indicating critical immunological changes.

Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider