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September 10, 2025BMC CancerOpen Access

Peripheral EBV antigen-specific T cell is dysfunctional in Epstein–Barr virus positive diffuse large B-cell lymphoma

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Observational study finds impaired T cell function in EBV-positive diffuse large B-cell lymphoma patients, implying immune evasion.

Impaired T cell function in EBV + DLBCL patients is characterized by lower IFN-γ levels compared to EBV- DLBCL.
Significant decline in CD8+ T cell subsets in EBV + DLBCL indicates a shift in immune cell distribution and heightened exhaustion.
The study utilized flow cytometry and ELISPOT to analyze T cell phenotypes and cytokine responses in lymphoma patients.
Findings suggest that targeting T cell dysfunction may improve treatment strategies in EBV-positive diffuse large B-cell lymphoma.

Gao et al. (2025) studied this question.

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