Key result
Cardiac myxoma resection significantly decreased IL-6 and CRP levels at one month, with IL-6 levels directly correlating with myxoma maximal dimension and volume.
Why the study?
To disclose the relationships between the anatomic features of cardiac myxomas and plasma interleukin-6 levels.
Does cardiac myxoma resection reduce circulating IL-6 levels, and do these levels correlate with tumor anatomic features?
Observational (n=12)
No
Does cardiac myxoma resection reduce circulating IL-6 levels, and do these levels correlate with tumor anatomic features?
Anatomic features of cardiac myxomas correlate with circulating IL-6 levels, which significantly decrease after resection, suggesting IL-6 is a sensitive biomarker for inflammatory status in these patients.
May support IL-6 as myxoma inflammation biomarker; hypothesis-generating, requires validation before clinical use.
OBJECTIVE: To disclose the relationships between the anatomic features of cardiac myxomas and plasma interleukin (IL)-6 levels. METHODS: Twelve patients undergoing cardiac myxoma resection at The First Hospital of Putian, Teaching Hospital, Fujian Medical University were enrolled into this study. Pre- and postoperative IL-6 levels were determined by an enzyme-linked immunosorbent assay method, and correlations between cardiac myxoma dimension or volume and plasma IL-6 levels were analyzed. C-reactive protein (CRP) levels were also evaluated. RESULTS: IL-6 and CRP levels were significantly decreased one month after cardiac myxoma resection in comparison to preoperative values. IL-6 and CRP levels did not differ between patients with a cardiac myxoma of irregular appearance and those with a myxoma of regular gross appearance, or between patients with a pedicled or a sessile myxoma. Decrement of IL-6 of patients with irregular cardiac myxomas was much higher than that of patients with regular ones, while no intergroup difference was noted in decrement of CRP. A close direct correlation was noted between IL-6 levels and maximal dimension (length) or volume of cardiac myxomas, whereas CRP levels only correlated with maximal dimension of cardiac myxomas. CONCLUSION: Anatomic features of cardiac myxomas (sessile, irregular appearance, maximal dimension, and volume) could be determinants of the patients' circulating IL-6 levels. IL-6 was likely to be a more sensitive biomarker than CRP in predicting the inflammatory status of patients with cardiac myxoma. Sessile and irregular cardiac myxomas might predict more severe inflammatory conditions for their more abundant endothelial cells and IL-6 overproduction.
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Yuan et al. (2019) conducted an observational in Cardiac myxoma (n=12). Cardiac myxoma resection and anatomic features vs. Preoperative values and regular myxoma appearance was evaluated on Plasma interleukin-6 (IL-6) and C-reactive protein (CRP) levels. Cardiac myxoma resection significantly decreased IL-6 and CRP levels at one month, with IL-6 levels directly correlating with myxoma maximal dimension and volume.
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