Key result
Interleukin-6 is specifically linked to immunological features in patients with cardiac myxomas.
Why the study?
The relationship between serum cytokine levels and immunological features in patients with cardiac myxomas was unclear.
Case Report (n=3)
Interleukin-6 levels correlate with immunological features in patients with cardiac myxomas, while atrial natriuretic peptide levels reflect haemodynamic changes rather than the tumour itself.
May link IL-6 to myxoma constitutional symptoms; leaves open causal role and therapeutic implications.
Serum levels of various cytokines were measured in three patients with cardiac myxomas presenting with and without constitutional symptoms, immunological features and elevated plasma levels of interleukin-6. Interleukin-6 but not other cytokines (interleukin-1, tumour necrosis factor-alpha, interferon-gamma) relate to immunological features of the patients. Circulating levels of atrial natriuretic peptide correspond to haemodynamic changes but not to the tumour-bearing state itself.
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Wiedermann et al. (1992) conducted a case report in Cardiac myxomas (n=3). Serum levels of cytokines (Interleukin-6) was evaluated on Relationship between cytokine levels and immunological features. Interleukin-6, but not other cytokines (interleukin-1, tumour necrosis factor-alpha, interferon-gamma), related to immunological features in patients with cardiac myxomas.
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