Key result
Resection of an interleukin-6-producing cardiac myxoma resulted in normalization of serum IL-6 levels and complete resolution of associated mediastinal lymphadenopathy in a 68-year-old female.
Why the study?
Does resection of an IL-6-producing cardiac myxoma resolve associated mediastinal lymphadenopathy?
Case Report (n=1)
Does resection of an IL-6-producing cardiac myxoma resolve associated mediastinal lymphadenopathy?
Resection of an IL-6-producing cardiac myxoma can lead to the resolution of associated mediastinal lymphadenopathy.
IL-6-secreting myxomas may cause reversible mediastinal lymphadenopathy; leaves open broader diagnostic role pending larger series.
We report our experience with a patient whose mediastinal lymphadenopathy resolved after resection of a cardiac myxoma that secreted interleukin-6 (IL-6). The patient was a 68-year-old female who complained of nocturnal chest discomfort related to congestive heart failure. An echocardiogram demonstrated a large left atrial mass. A computed tomogram showed not only the left atrial mass but multiple enlarged mediastinal lymph nodes. The serum IL-6 level was markedly elevated at 13.7 pg/ml. After resection of the cardiac myxoma, serum IL-6 returned to the normal range. A repeat computed tomogram showed no mediastinal lymphadenopathy. We believe that overproduction of IL-6 by the cardiac myxoma was the cause of the mediastinal lymphadenopathy.
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Takizawa et al. (1999) conducted a case report in Cardiac myxoma with mediastinal lymphadenopathy (n=1). Resection of cardiac myxoma was evaluated on Resolution of mediastinal lymphadenopathy and normalization of serum IL-6. Resection of an interleukin-6-producing cardiac myxoma resulted in normalization of serum IL-6 levels and complete resolution of associated mediastinal lymphadenopathy in a 68-year-old female.
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