Key result
Transplantation of AT1a receptor-deficient visceral adipose tissue markedly attenuated aortic aneurysm formation, macrophage infiltration, and gelatinolytic activity in ApoE-/- mice.
Why the study?
Does genetic deletion of the angiotensin II type 1a (AT1a) receptor in perivascular visceral adipose tissue attenuate aortic aneurysm formation in ApoE-/- mice?
Population
Apolipoprotein E-deficient (ApoE-/-) mice with an angiotensin II-induced aneurysm murine model
Comparison
Transplantation of visceral adipose tissue from… vs Transplantation of visceral adipose tissue from…
Design
Preclinical
Authors
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Identifies perivascular AT1a as AAA target in mice; hypothesis-generating and leaves open human translation.
Does genetic deletion of the angiotensin II type 1a (AT1a) receptor in perivascular visceral adipose tissue attenuate aortic aneurysm formation in ApoE-/- mice?
Deletion of the AT1a receptor in perivascular visceral adipose tissue attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice, highlighting a novel pathogenic mechanism and potential therapeutic target.
Sakaue et al. (2017) studied Abdominal aortic aneurysm. ApoE-/- AT1a-/- visceral adipose tissue (VAT) transplantation vs. ApoE-/- VAT transplantation was evaluated on Aortic aneurysm formation, macrophage infiltration, and gelatinolytic activity. Transplantation of AT1a receptor-deficient visceral adipose tissue markedly attenuated aortic aneurysm formation, macrophage infiltration, and gelatinolytic activity in ApoE-/- mice.
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