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June 12, 2026Radiology Cardiothoracic Imaging0 citations

Comparison between Dark-Blood LGE Sequence and Standard Bright-Blood LGE in the Assessment of Ventricular Myocardial Scarring: A Systematic Review and Meta-Analysis

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TPThiago de Gaultier PauloSAStephan AltmayerGTGiovanni Torri

Key Result

Dark-blood LGE yielded higher myocardial scar detection and scar-to-blood contrast than bright-blood LGE, particularly for ischemic patterns and papillary muscle fibrosis.

Key Points

  • This research examines the effectiveness of dark-blood LGE versus bright-blood LGE in detecting myocardial scars.
  • Conducted a systematic review and meta-analysis comparing detection rates of dark-blood and bright-blood LGE.
  • Focused on myocardial scarring assessments including ischemic patterns and fibrosis in papillary muscles.
  • Dark-blood LGE identified more myocardial scars compared to bright-blood LGE, enhancing scar-to-blood contrast.
  • Significant improvement in detecting ischemic myocardial lesions.
  • Higher effectiveness noted in identifying papillary muscle fibrosis.

Structured PICO

Does dark-blood LGE improve myocardial scar detection and scar-to-blood contrast compared to standard bright-blood LGE in patients undergoing assessment of ventricular myocardial scarring?

P
Population
Patients undergoing assessment of ventricular myocardial scarring
I
Intervention
Dark-blood late gadolinium enhancement (LGE) sequence
C
Comparator
Standard bright-blood LGE
O
Outcome
Myocardial scar detection and scar-to-blood contrastsurrogate

Dark-blood LGE provides superior myocardial scar detection and scar-to-blood contrast compared to standard bright-blood LGE, especially for ischemic patterns and papillary muscle fibrosis.

Abstract

Dark-blood late gadolinium enhancement (LGE) was associated with higher myocardial scar detection and scar-to-blood contrast than bright-blood LGE, particularly for ischemic patterns and papillary muscle fibrosis.

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Cite This Study

Paulo et al. (2026) studied this question. Dark-blood LGE yielded higher myocardial scar detection and scar-to-blood contrast than bright-blood LGE, particularly for ischemic patterns and papillary muscle fibrosis.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe90chttps://doi.org/10.1148/ryct.250567
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Value of Cardiac MRI Late Gadolinium Enhancement Granularity in Participants with Ischemic Cardiomyopathy2025 · 13 citations
  2. 2Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance2024 · 26 citations
  3. 3Improved Detection of Subendocardial Hyperenhancement in Myocardial Infarction Using Dark Blood–Pool Delayed Enhancement MRI2011 · 41 citations
  4. 4Prognostic Value of Papillary Muscle Scarring in Patients With Dilated Cardiomyopathy2025 · 3 citations
  5. 5Dark-blood late gadolinium-enhancement cardiac magnetic resonance imaging for myocardial scar detection based on simplified timing scheme: single-center experience in patients with suspected coronary artery disease2021 · 8 citations