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June 12, 2026European Journal of Preventive Cardiology

Hemostatic derangements in diverse atherosclerotic cardiovascular disease presentations

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Key result

Stable CAD and PAD link to decreased fibrinolysis while AMI shows increased coagulation versus healthy controls.

  • n=436

Why the study?

Hypercoagulability is a major determinant of atherosclerosis, but differences between diverse atherosclerotic cardiovascular disease presentations remain understudied.

Do hemostatic profiles differ between apparently healthy individuals and patients with different presentations of atherosclerotic cardiovascular disease (stable CAD, PAD, or recent AMI)?

Population

436 individuals, including healthy controls, stable CAD, post-MI, and PAD patients

Comparison

Hemostasis across healthy individuals, stable CAD, symptomatic PAD, and post-MI

Design

Cross-sectional study

Authors

DKD KosutaLjubljana University Medical CentreMMM Bozic MijovskiLjubljana University Medical CentreBJB JugLjubljana University Medical Centre

Discussion

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Implication

Does not support routine hemostatic testing in ASCVD; leaves open targeted antithrombotic trials in high-OHP subgroups.

Key Points

  • This study aims to investigate hemostatic differences among healthy individuals and patients with various types of atherosclerotic cardiovascular diseases (ASCVD).
  • Cross-sectional study design recruiting 436 individuals at risk for ASCVD including healthy individuals, those with stable CAD, PAD, and post-MI patients.
  • Determination of overall hemostatic potential (OHP), overall coagulation potential (OCP), and overall fibrinolytic potential (OFP) from peripheral blood samples.
  • Statistical assessment of differences using one-way ANOVA, Kruskall-Wallis test, and χ2 test with Bonferroni adjustment for multiple comparisons.
  • Out of 436 individuals, healthy participants had lower OHP compared to CAD patients, with myocardial infarction patients showing higher OHP, while PAD patients had the highest OHP.
  • Patients with myocardial infarction exhibited significantly higher OCP than others.
  • OFP was highest in healthy individuals, followed by myocardial infarction patients, while it was lower in stable CAD cases and lowest in PAD patients.

Study Design

Type

Cross-Sectional (n=436)

Structured PICO

Do hemostatic profiles differ between apparently healthy individuals and patients with different presentations of atherosclerotic cardiovascular disease (stable CAD, PAD, or recent AMI)?

P
Population
436 individuals (mean age 62.7 years, 36.9% women) including apparently healthy individuals, patients with stable CAD, patients with PAD, and patients after AMI.
C
Comparator
Apparently healthy individuals (no signs of CAD on CCTA)
O
Outcome
Hemostasis measurements including overall hemostatic potential (OHP), overall coagulation potential (OCP), and overall fibrinolytic potential (OFP)surrogate

Different presentations of atherosclerotic cardiovascular disease are associated with distinct hemostatic imbalances, highlighting specific prothrombotic mechanisms in stable CAD, PAD, and recent AMI.

Cite This Study

Kosuta et al. (2026) conducted a cross-sectional in Atherosclerotic cardiovascular disease (ASCVD) (n=436). Atherosclerotic cardiovascular disease presentations (stable CAD, PAD, AMI) vs. Apparently healthy individuals was evaluated on Hemostasis measurements (Overall hemostatic potential, overall coagulation potential, overall fibrinolytic potential). Compared to healthy individuals, patients with stable CAD and PAD exhibited decreased fibrinolysis, whereas patients after AMI showed increased coagulation.

synapsesocial.com/papers/6a2bd1386550ea4541ffe9d5https://doi.org/10.1093/eurjpc/zwag249.205
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex differences in the effect of physical activity on hemostasis in coronary artery disease2026
  2. 2Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART‐CT Study2021 · 15 citations
  3. 3Abstract 11647: Influence of Hypercoagulability and Impaired Fibrinolysis on Occurrence of Acute Myocardial Infarction and Prognostic Implication Following Percutaneous Coronary Intervention2021
  4. 4Blood Changes in Atherosclerosis and Long After Myocardial Infarction and Venous Thrombosis1975 · 46 citations
  5. 5Association of Variables of Coagulation, Fibrinolysis and Acute-phase with Atherosclerosis in Coronary and Peripheral Arteries and those Arteries Supplying the Brain1995 · 203 citations