Key result
Global coagulation profiles correlate with CAC and Gensini scores in men but not women.
Why the study?
Individual assays have been of minimal value in understanding disease susceptibility regarding dysregulated coagulation and atherosclerosis, prompting investigation into global coagulation profiles and CAD with consideration of sex differences.
Are global coagulation profiles associated with coronary artery disease severity and cardiovascular risk factors differently in men and women?
Population
206 adult patients referred for clinically indicated CT coronary angiography
Comparison
Global coagulation profiles across sexes and CAD severity
Design
Observational biobank study
Authors
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Hypothesis-generating for sex-specific coagulation roles in CAD; prospective studies needed before clinical consideration.
Observational (n=206)
Are global coagulation profiles associated with coronary artery disease severity and cardiovascular risk factors differently in men and women?
Global coagulation profiles, specifically the overall hemostatic potential assay, correlate with coronary artery disease severity in men but not women, highlighting sex-specific pathophysiological differences in atherosclerosis.
Kott et al. (2021) conducted an observational in Coronary artery disease (n=206). Global coagulation profiles (overall hemostatic potential and calibrated automated thrombography assays) was evaluated on Coronary artery calcium score (CACS) and Gensini score. Global coagulation profiles measured by the overall hemostatic potential assay were significantly correlated with coronary artery calcium and Gensini scores in men, but not in women.
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