Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1975Thrombosis and Haemostasis

Blood Changes in Atherosclerosis and Long After Myocardial Infarction and Venous Thrombosis

View Full Paper
Ask AI
Bookmark
Share

Population

Patients long after recovery from myocardial infarction, deep vein thrombosis, intermittent claudication…

Design

Case-control

Authors

JOJohn O’BrienUniversity of HoustonMEM.D. EtheringtonUniversity of Pittsburgh Medical CenterSJSandra JamiesonIsle of Wight NHS Trust

Discussion

Loading...

Member takes

Implication

May indicate persistent procoagulant state post-MI; hypothesis-generating for HNA monitoring, requiring prospective validation before clinical use.

Structured PICO

P
Population
Patients long after recovery from myocardial infarction (MI), deep vein thrombosis (DVT), intermittent claudication, diabetes (n=9), and matched male and female controls (n=66 for male patients and controls combined).
C
Comparator
Matched male and female controls
O
Outcome
Platelet and clotting tests including heparin neutralizing activity (HNA), anti-thrombin levels, bleeding time, and platelet sizesurrogate

Patients with atherosclerosis, prior MI, or DVT exhibit persistent pro-coagulant blood changes, including increased heparin neutralizing activity and decreased anti-thrombin, suggesting ongoing minor intravascular coagulation.

Cite This Study

O’Brien et al. (1975) studied this question.

synapsesocial.com/papers/6a85488bff13e6e4e743df41https://doi.org/10.1055/s-0038-1651407
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemostatic derangements in diverse atherosclerotic cardiovascular disease presentations2026
  2. 2Measurement of thrombosis and its prevention2002 · 13 citations
  3. 3Editorial: Women in thrombosis2023
  4. 4Haemostatic variables associated with diabetes and its complications.1979 · 288 citations
  5. 5Hemostatic risk factors in patients with coronary artery disease and type 2 diabetes - a two year follow-up of 243 patients2009 · 41 citations