Maternal sociodemographic, pre-pregnancy, and pregnancy factors, particularly pre-pregnancy BMI and diabetes, were significantly associated with early-onset type 2 diabetes (453 cases).
Cohort (n=303,037)
Are maternal sociodemographic, prepregnancy, and pregnancy factors associated with early-onset type 2 diabetes in adolescents and young adults?
Maternal factors, particularly pre-pregnancy BMI and diabetes, are strongly associated with the development of early-onset type 2 diabetes in offspring, highlighting targets for early-life intervention.
Introduction and Objective: Youth type 2 diabetes (T2D) rates have risen globally. Preconception and pregnancy are sensitive periods for later T2D risk, yet contributing exposures remain unclear. We examined associations between maternal and pregnancy factors and early-onset T2D in the Predictors of Adverse Cardiometabolic Problems in Adolescents and Young Adults (PAPAYA) study at Kaiser Permanente Northern California (KPNC). Methods: This retrospective cohort included 303,037 individuals born at KPNC in 2003-2011. Maternal (education, age, parity, Medicaid status, pre-pregnancy BMI and diabetes) and pregnancy (gestational diabetes, preeclampsia, preterm birth, delivery mode) factors were obtained from electronic health records and birth certificates. Early-onset T2D (ages 10-21; N=453) was identified via the KPNC Diabetes Registry. Cox proportional hazards models estimated hazard ratios adjusting for confounders. Results: The cohort was 48.8% female and racially diverse (37.7% White, 25.5% Hispanic, 19.6% Asian/Pacific Islander, 7.0% Black, 0.3% Native American, 9.9% Other). Associations were significant in all models except preterm birth and delivery mode, with strongest effect estimates for pre-pregnancy BMI and diabetes (see Table). Conclusion: Several maternal sociodemographic, pre-pregnancy, and pregnancy factors were associated with early-onset T2D, providing targets for early-life interventions. Disclosure S. Daredia: None. S. Aghaee: None. J. Acker: None. J.Y. Liu: None. C.J. Huang: None. A. Karter: Research Support; Current; Dexcom, Inc. A. Kubo: None. J. Deardorff: None. Funding National Heart Lung and Blood Institute (1R01HL177516-01); National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK139116-01A1)
Daredia et al. (Fri,) conducted a cohort in Type 2 Diabetes (n=303,037). Maternal sociodemographic, pre-pregnancy, and pregnancy factors was evaluated on Early-onset type 2 diabetes. Maternal sociodemographic, pre-pregnancy, and pregnancy factors, particularly pre-pregnancy BMI and diabetes, were significantly associated with early-onset type 2 diabetes (453 cases).