Key result
Depression in patients undergoing percutaneous coronary intervention was associated with an increased risk of adverse medical outcomes (RR 1.57; 95% CI 1.28-1.92; p<0.0001).
Why the study?
To assess whether depression in patients undergoing percutaneous coronary intervention is associated with a higher risk of adverse outcomes.
Does depression increase the risk of adverse cardiovascular outcomes and mortality in patients undergoing percutaneous coronary intervention?
Meta-Analysis (n=3,297)
Does depression increase the risk of adverse cardiovascular outcomes and mortality in patients undergoing percutaneous coronary intervention?
Relative Risk: 1.57 (95% CI 1.28–1.92)
p-value: p=<0.0001
Depression is a significant predictor of adverse cardiovascular outcomes and all-cause mortality in patients undergoing percutaneous coronary intervention, highlighting the prognostic importance of psychological assessment in this population.
Supports depression assessment in PCI patients; leaves open whether treating depression reduces adverse outcomes.
OBJECTIVES: The objective of this meta-analysis was to assess whether depression in percutaneous coronary intervention (PCI) patients is associated with higher risk of adverse outcomes. DESIGN: Systematic review and meta-analysis. METHODS: EMBASE, PubMed, CINAHL and PsycINFO were searched as data sources. We selected prospective cohort studies evaluating the relationship between depression and any adverse medical outcome, including all-cause mortality, cardiac mortality and non-fatal events, from inception to 28 February 2019. Two reviewers independently extracted information and calculated the risk of cardiovascular events in patients with preoperative or postoperative depression compared with non-depressed patients. RESULTS: Eight studies (n=3297) met our inclusion criteria. Most studies found a positive association between depression and adverse cardiovascular outcomes. Meta-analysis yielded an aggregate risk ratio of 1.57 (95% CI 1.28 to 1.92, p<0.0001) for the magnitude of the relation between depression and adverse outcomes. CONCLUSIONS: Our systematic review and meta-analysis suggests that depression is associated with an increased risk of worse clinical outcome or mortality in patients undergoing PCI. Assessment time and length of follow-up do not have a significant effect on this conclusion.
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Zhang et al. (2019) conducted a meta-analysis in Percutaneous coronary intervention (PCI) (n=3,297). Depression vs. Non-depressed patients was evaluated on Adverse medical outcome, including all-cause mortality, cardiac mortality and non-fatal events (RR 1.57, 95% CI 1.28 to 1.92, p=<0.0001). Depression in patients undergoing percutaneous coronary intervention was associated with an increased risk of adverse medical outcomes (RR 1.57; 95% CI 1.28-1.92; p<0.0001).