Key result
The PIVOT MRI sequence allowed simultaneous quantification of perfusion, venous oxygen saturation, and skeletal muscle T2* without significant bias compared to standard individual measurement techniques.
Why the study?
Does the PIVOT MRI sequence accurately measure perfusion, venous oxygen saturation, and T2* simultaneously compared to standard separate methods during reactive hyperemia?
Observational (n=10)
No
Does the PIVOT MRI sequence accurately measure perfusion, venous oxygen saturation, and T2* simultaneously compared to standard separate methods during reactive hyperemia?
p-value: p=>0.05
The PIVOT MRI sequence allows for accurate, simultaneous quantification of perfusion, venous oxygen saturation, and T2* in the peripheral microvasculature, which may help evaluate microvascular function in patients with peripheral artery disease.
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May facilitate efficient microvascular phenotyping in PAD; leaves open prospective validation before clinical adoption.
Englund et al. (2013) conducted an observational in Peripheral Artery Disease (n=10). PIVOT (Perfusion, Intravascular Venous Oxygen saturation, and T2*) MRI sequence vs. Standard individual measurement methods (PASL-only and multi-echo GRE-only) was evaluated on Difference in key time-course parameters (perfusion, SvO2, T2*) between PIVOT and standard measurement methods (p=>0.05). The PIVOT MRI sequence allowed simultaneous quantification of perfusion, venous oxygen saturation, and skeletal muscle T2* without significant bias compared to standard individual measurement techniques.
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