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This study evaluated weight change and metabolic effects in obese women with PCOS after stopping semaglutide while continuing metformin.

June 13, 2026FrontiersOpen Access

The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin

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Authors

MSMojca Jensterle Sever SFSimona FerjanUniversity of Ljubljana JAJanež, Andrej, 1971- autoth(SI-MaCOB)4627555Ljubljana University Medical Centre

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Implication

Randomized trial examines weight loss maintenance after halting semaglutide in obese women with PCOS, suggesting metformin aids sustained weight loss.

Key Points

This study evaluated weight change and metabolic effects in obese women with PCOS after stopping semaglutide while continuing metformin.
25 obese women with PCOS were treated with semaglutide and metformin for 16 weeks.
Following semaglutide withdrawal, participants continued metformin and lifestyle changes for 2 years.
Weight and metabolic parameters were assessed at baseline and after 2 years post-semaglutide.
Mean weight decreased from 101 kg to 92 kg during semaglutide treatment (p=0.003 for baseline comparison).
Two years after semaglutide withdrawal, subjects regained one-third of the initial weight loss, averaging 95 kg.
84% of women maintained lower body weight than their baseline after 2 years.

Cite This Study

Sever et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055a5e https://doi.org/10.3389/fendo.2024.1366940/abstract

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Implication

Randomized trial examines weight loss maintenance after halting semaglutide in obese women with PCOS, suggesting metformin aids sustained weight loss.

The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin

Discussion

Member takes

Implication

Key Points

Cite This Study

The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin

Discussion

Member takes

Implication

Key Points

Cite This Study

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