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June 13, 2026

Neurocognitive Late Effects Among Childhood Cancer Survivors: A Holistic Review of Clinical Risk Factors.

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Authors

RWRachel S. WerkKLKatharine R. Lange

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Overview

Holistic review highlights clinical risk factors affecting neurocognitive outcomes in childhood cancer survivors, suggesting improved screening opportunities.

Key Points

  • To assess the clinical risk factors that contribute to neurocognitive deficits in childhood cancer survivors.
  • Holistic review of existing literature on neurocognitive effects and clinical risk factors.
  • Discussion on screening opportunities for clinicians to better support survivors.
  • Identification of various factors related to cancer treatment and outcomes.
  • Neurocognitive deficits are associated with treatment received and involvement of the central nervous system.
  • Multiple clinical factors impacting neurocognition in childhood cancer survivors are identified.
  • Opportunities for improvement in clinician screening and care practices are suggested.

Cite This Study

Werk et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056232https://doi.org/10.1016/j.hoc.2026.02.003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overcoming emerging challenges in childhood cancer survivorship: a spotlight on pediatric CNS tumors2026
  2. 2Late-onset Cognitive Impairment and Modifiable Risk Factors in Adult Childhood Cancer Survivors2023 · 65 citations
  3. 3Chronic Health Conditions and Neurocognitive Function in Aging Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study2017 · 98 citations
  4. 4Long-term effects of treatments for childhood cancers2007 · 114 citations
  5. 5Postacute Neurocognitive Sequelae Following Pediatric Chemotherapy: A Retrospective Study From the Montefiore Survivorship Clinic (2000-2024)2026