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February 1, 2007Current Opinion in Pediatrics

Long-term effects of treatments for childhood cancers

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Population

Long-term survivors of childhood cancer

Design

Review

Authors

JAJorge A. AlvarezRSRebecca E. ScullyTMTracie L. Miller

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Overview

Lifelong cardiac surveillance remains essential for childhood cancer survivors; supports dexrazoxane use but leaves open optimal strategies in prospective studies.

Structured PICO

P
Population
Long-term survivors of childhood cancer
I
Intervention
Childhood cancer treatments (including anthracyclines and radiotherapy) and mitigation strategies (e.g., dexrazoxane)
O
Outcome
Late cardiac, endocrine, and neurological effects

Lifelong multidisciplinary monitoring is required for childhood cancer survivors due to the high frequency and severity of late toxicities, including progressive cardiotoxicity.

Cite This Study

Alvarez et al. (2007) studied this question.

synapsesocial.com/papers/6a87d5b2c61576201cfb0b57https://doi.org/10.1097/mop.0b013e328013c89e
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Disease2011 · 113 citations
  2. 2Late Effects of Childhood Cancer: Life-threatening Issues2008 · 20 citations
  3. 3Cardiotoxicity related to cancer therapy1998 · 3 citations
  4. 4Cardiotoxicity of Childhood Cancer Treatment: Update and Current Knowledge on Long-term Follow-up2012 · 16 citations
  5. 5Diagnosis and Management of Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Children2023 · 30 citations