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January 1, 1998Progress in Pediatric CardiologyOpen Access

Cardiotoxicity related to cancer therapy

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Key result

Non-cardiac sequelae of childhood cancer therapy link to significant cardiovascular impacts in survivors.

Why the study?

What are the cardiovascular effects of non-cardiac sequelae resulting from childhood cancer treatment?

Population

Childhood cancer survivors

Design

Review

Authors

AHAndrea S. HinkleUniversity of IndianapolisSTSusie C. TruesdellStrong Memorial HospitalCPC. ProukouUniversity of Miami

Discussion

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Implication

Non-cardiac late effects may compound CV risk in survivors; prospective cohorts needed to refine surveillance.

Structured PICO

What are the cardiovascular effects of non-cardiac sequelae resulting from childhood cancer treatment?

P
Population
Childhood cancer survivors
E
Exposure
Cancer therapy and its non-cardiac sequelae (e.g., thyroid dysfunction, growth hormone deficiency, obesity, ovarian failure, pulmonary disease, renal dysfunction, psychosocial issues)
O
Outcome
Cardiovascular effects and cardiac function

Understanding the cardiovascular impact of non-cardiac late effects of childhood cancer treatment is essential to lessen associated morbidity and mortality in survivors.

Cite This Study

Hinkle et al. (1998) conducted a review in Childhood cancer survivors. Childhood cancer therapy was evaluated. Childhood cancer therapy is associated with non-cardiac late sequelae, such as thyroid dysfunction, obesity, and pulmonary disease, which can significantly impact cardiovascular status in survivors.

synapsesocial.com/papers/6aa5ff9fe46a8f6037922298https://doi.org/10.1016/s1058-9813(98)00010-1
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