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June 13, 2026BMC CancerOpen Access

Prognostic significance of therapy-induced senescence and SASP dynamics in acute myeloid leukemia: a retrospective cohort study

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Authors

BMBing MaLZLihong Zhang

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Overview

Retrospective cohort study evaluates senescence burden in acute myeloid leukemia, suggesting implications for treatment strategies.

Key Points

  • This study aims to determine the prognostic significance of therapy-induced senescence and SASP dynamics in acute myeloid leukemia.
  • Assessed senescence and SASP factors in bone marrow plasma by ELISA.
  • Patients were divided into High-Senescence and Low-Senescence groups based on median cut-off values.
  • Flow cytometry was used to evaluate senescence markers and SA-β-gal activity.
  • High senescence burden post-induction is linked to worse outcomes (HR 1.98, 95% CI 1.15-3.40).
  • The presence of SASP factors correlated with the poor prognosis in acute myeloid leukemia.
  • Therapy-induced senescence fosters a pro-tumoral microenvironment that may lead to leukemic relapse.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056320https://doi.org/10.1186/s12885-026-16171-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Construction and validation of a <scp>SASP</scp>‐related prognostic signature in patients with acute myeloid leukaemia2024 · 2 citations
  2. 2Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity2026
  3. 3Cancer therapy-induced senescence: A critical yet overlooked aspect2026
  4. 4Cellular senescence associated with aging and chemotherapy exposure primes bone marrow for immune dysfunction and myeloma persistence2025
  5. 5Mesenchymal stem cells-like as a prognostic biomarker in patients diagnosed with acute myeloid leukemia2025