Cannabidiol in Refractory Epilepsy: Meta-analysis of Seizure Freedom and Responder Rates Across Syndromes (P8-11.001)

Omar Elmandouh; Ana Leticia Fornari Caprara; Jamir Pitton Rissardo; Salman Assad; Evren Burakgazi-Dalkilic; Eric P. Nagele

doi:10.1212/wnl.0000000000213060

June 9, 2026Neurology

Cannabidiol in Refractory Epilepsy: Meta-analysis of Seizure Freedom and Responder Rates Across Syndromes (P8-11.001)

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Key Points

The research assesses how well cannabidiol can help patients achieve seizure freedom and significant reduction in seizure frequency.
Meta-analysis of data from multiple studies on cannabidiol use in epilepsy syndromes.
Focus on patients with Dravet syndrome, Lennox–Gastaut syndrome, and Tuberous Sclerosis Complex.
Comparison of seizure freedom and responder rates across these conditions.
Cannabidiol demonstrated a significant increase in seizure freedom rates across the evaluated syndromes.
Responder rates of ≥50% were meaningfully higher in patients treated with cannabidiol compared to baseline measures.

Implication

Meta-analysis evaluates cannabidiol efficacy for seizure freedom rates in refractory epilepsy syndromes, indicating potential treatment benefits.

Abstract

To evaluate the efficacy of cannabidiol (CBD) in achieving seizure freedom (SF) and ≥50% responder rates (RR50) in patients with Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and Tuberous Sclerosis Complex (TS).

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Cite This Study

Elmandouh et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056333 https://doi.org/10.1212/wnl.0000000000213060

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Cannabidiol in Refractory Epilepsy: Meta-analysis of Seizure Freedom and Responder Rates Across Syndromes (P8-11.001)

Key Points

Implication

Abstract

Discussion

Cite This Study

Cannabidiol in Refractory Epilepsy: Meta-analysis of Seizure Freedom and Responder Rates Across Syndromes (P8-11.001)

Key Points

Implication

Abstract

Discussion

Cite This Study

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