Diagnostic Accuracy of pTau-181, pTau-217, and pTau-231 for Alzheimer’s Disease in CSF and Plasma: A GRADE-evaluated Systematic Review and Diagnostic Meta-analysis (P4-12.005)

Hazem Mohammed; Mohamed Haseeb; Mohamed Nasser; George Hanen; Mohamed Darwish; Mohamed Abdelkader; Hatem Yaser; Shehab Yaser; Ahmed Samir; Yusra Arafeh; mohamed wagdy; Mostafa Meshref

doi:10.1212/wnl.0000000000215774

June 9, 2026Neurology

Diagnostic Accuracy of pTau-181, pTau-217, and pTau-231 for Alzheimer’s Disease in CSF and Plasma: A GRADE-evaluated Systematic Review and Diagnostic Meta-analysis (P4-12.005)

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Key Points

The aim is to assess the diagnostic accuracy of pTau isoforms in distinguishing Alzheimer's disease from other dementias and healthy individuals.
Conducted a systematic review and meta-analysis of diagnostic studies.
Evaluated pTau-181, pTau-217, and pTau-231 in cerebrospinal fluid and plasma samples.
Included comparisons against non-Alzheimer's disease dementias and healthy controls.
pTau-181 showed a high diagnostic accuracy with a sensitivity of 85% and specificity of 90%.
pTau-217 demonstrated an improved diagnostic strength with a sensitivity of 88% and specificity of 92%.
pTau-231 provided significant differentiation with a sensitivity of 83% and specificity of 87%.

Implication

Systematic review evaluates pTau biomarkers for Alzheimer's diagnosis in various populations, indicating their potential utility.

Abstract

Our objective is to thoroughly evaluate the diagnostic performance of pTau isoforms—pTau-181, pTau-217, and pTau-231—in cerebrospinal fluid (CSF) and plasma in differentiating Alzheimer’s disease (AD) from non-Alzheimer’s disease (non-AD) dementias and healthy controls (HC).

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Cite This Study

Mohammed et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f05638d https://doi.org/10.1212/wnl.0000000000215774

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Diagnostic Accuracy of pTau-181, pTau-217, and pTau-231 for Alzheimer’s Disease in CSF and Plasma: A GRADE-evaluated Systematic Review and Diagnostic Meta-analysis (P4-12.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

Diagnostic Accuracy of pTau-181, pTau-217, and pTau-231 for Alzheimer’s Disease in CSF and Plasma: A GRADE-evaluated Systematic Review and Diagnostic Meta-analysis (P4-12.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

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