What question did this study set out to answer?

This study aims to evaluate the association between remnant cholesterol variability and all-cause as well as cardiovascular mortality.

June 13, 2026European Journal of Preventive CardiologyOpen Access

Remnant cholesterol variability and the risk of all-cause and cardiovascular mortality: findings from a prospective community-based cohort study

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: General population (n=6650). Intervention: Remnant cholesterol variability vs. Lower remnant cholesterol variability. Primary outcome: all-cause mortality (HR 1.16, 95% CI 1.06-1.26, p=0.001).

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Key result

Higher remnant cholesterol variability is linked to ~16% greater all-cause mortality risk per SD.

HR 1.16
95% CI 1.06-1.26
P=0.001
n=6,650

Why the study?

Does higher remnant cholesterol variability increase the risk of all-cause and cardiovascular mortality in adults?

Population

6,650 adults ≥30 years from the Tehran Lipid and Glucose Study with ≥2 remnant cholesterol measurements…

Comparison

Higher remnant cholesterol variability vs Lower remnant cholesterol variability

Design

Cohort

Follow-up

median 10.2 years after the exposure window

Authors

AAA AbdiResearch Institute for Endocrine Sciences NCN CheraghlooResearch Institute for Endocrine Sciences FAF AziziResearch Institute for Endocrine Sciences

Discussion

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Implication

Higher variability in remnant cholesterol is independently associated with an increased risk of all-cause and cardiovascular mortality, suggesting its potential utility in cardiovascular risk stratification.

Key Points

This study aims to evaluate the association between remnant cholesterol variability and all-cause as well as cardiovascular mortality.
Included adults ≥30 years from the Tehran Lipid and Glucose Study with ≥2 RC measurements.
RC calculated using total cholesterol minus HDL-C and LDL-C based on Martin–Hopkins equations.
Cox models with adjustments for multiple confounders were utilized.
Higher variability in remnant cholesterol is associated with increased all-cause mortality (HR 1.16 for SD change, 95% CI: 1.06-1.26, p=0.001).
The highest quartile of remnant cholesterol variability showed a 52% higher risk of all-cause mortality (HR 1.52, 95% CI: 1.15-2.00).
Significant associations were observed for cardiovascular mortality, with up to 86% increased risk in the highest variability quartile.

Study Design

Type

Cohort (n=6,650)

Structured PICO

Does higher remnant cholesterol variability increase the risk of all-cause and cardiovascular mortality in adults?

Population

6,650 adults aged ≥30 years from the Tehran Lipid and Glucose Study with ≥2 remnant cholesterol measurements, followed for a median of 10.2 years.

Exposure

Higher remnant cholesterol (RC) variability (quantified using standard deviation, variability independent of the mean, and average real variability)

Comparator

Lower remnant cholesterol variability (e.g., lowest quartile)

Outcome

All-cause mortality and cardiovascular mortalityhard clinical

Main Result

Hazard Ratio: 1.16 (95% CI 1.06–1.26)

p-value: p=0.001

Cite This Study

Abdi et al. (2026) conducted a cohort in General population (n=6,650). Remnant cholesterol variability vs. Lower remnant cholesterol variability was evaluated on all-cause mortality (HR 1.16, 95% CI 1.06-1.26, p=0.001). Higher remnant cholesterol variability (per 1-SD change) was significantly associated with an increased risk of all-cause mortality (HR 1.16; 95% CI 1.06-1.26; p=0.001).

synapsesocial.com/papers/6a2cf4aefaef96ed7f056ec0 https://doi.org/10.1093/eurjpc/zwag249.253

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Remnant cholesterol variability and the risk of all-cause and cardiovascular mortality: findings from a prospective community-based cohort study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Remnant cholesterol variability and the risk of all-cause and cardiovascular mortality: findings from a prospective community-based cohort study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider