Key result
Higher remnant cholesterol variability is linked to ~36% increased risk of incident hypertension.
Why the study?
Does higher variability of remnant cholesterol increase the risk of incident hypertension in adults?
Population
2,926 participants aged ≥ 20 years who underwent three sequential visits between 2002 and 2011
Comparison
Cumulative exposure to remnant cholesterol and… vs Lower variability of remnant cholesterol or…
Design
Cohort
Follow-up
median 6.12 years
Authors
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Higher variability in remnant cholesterol, rather than cumulative exposure, is associated with an increased risk of incident hypertension, suggesting a potential target for prevention.
Cohort (n=2,926)
Does higher variability of remnant cholesterol increase the risk of incident hypertension in adults?
Hazard Ratio: 1.36 (95% CI 1.07–1.74)
Higher variability in remnant cholesterol, rather than cumulative exposure, is associated with an increased risk of incident hypertension, suggesting a potential target for prevention.
Molavizadeh et al. (2025) conducted a cohort in Incident hypertension (n=2,926). Remnant cholesterol variability vs. Lowest quartile of variability (Q1) was evaluated on Incident hypertension (HR 1.36, 95% CI 1.07-1.74). Higher variability of remnant cholesterol (SD Q4 vs. Q1) was associated with an increased risk of incident hypertension (HR 1.36; 95% CI 1.07-1.74), whereas cumulative exposure was not.
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