June 13, 2026European Journal of Preventive CardiologyOpen Access

Cumulative exposure and variability of remnant cholesterol and the risk of cardiovascular disease: two decades of follow-up in a prospective community-based cohort

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Incident cardiovascular disease (CVD) (n=5805). Intervention: Cumulative remnant cholesterol (RC) exposure and RC variability vs. Lower cumulative RC exposure and variability. Primary outcome: Cardiovascular disease (CVD), defined as a composite of coronary heart disease (CHD) and stroke (HR 1.27, 95% CI 1.08-1.51).

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Key result

Higher cumulative remnant cholesterol burden is linked to ~27% higher incident CVD risk.

HR 1.27
95% CI 1.08-1.51
n=5,805

Why the study?

Does higher cumulative exposure and variability of remnant cholesterol increase the risk of incident cardiovascular disease in adults?

Population

5,805 adults aged ≥30 years from the Tehran Lipid and Glucose Study with ≥2 remnant cholesterol measurements…

Comparison

Higher cumulative remnant cholesterol exposure… vs Lower cumulative remnant cholesterol exposure…

Design

Cohort

Follow-up

median 10.1 years after exposure period

Authors

AAA AbdiResearch Institute for Endocrine Sciences NCN CheraghlooResearch Institute for Endocrine Sciences FAF AziziResearch Institute for Endocrine Sciences

Discussion

Member takes

Implication

Long-term cumulative exposure and variability of remnant cholesterol are independently associated with increased risk of incident cardiovascular disease, suggesting their potential utility in early risk stratification.

Key Points

The study aims to evaluate the relationship between cumulative exposure and variability of remnant cholesterol and the risk of cardiovascular disease.
Included adults aged ≥30 years from the Tehran Lipid and Glucose Study with ≥2 remnant cholesterol measurements during a median exposure of 6.1 years.
Cumulative exposure was assessed by averaging consecutive measurements and evaluating cumulative burden against predefined cutoffs.
Cox models adjusted for demographic and clinical factors were used to analyze the associations with cardiovascular disease.
Higher cumulative remnant cholesterol was associated with increased cardiovascular disease risk, with 28%, 47%, and 31% higher risk across quartiles Q2–Q4; p-trend = 0.039.
Cumulative remnant cholesterol burden also correlated with increased CVD risk, HR 1.27 (1.08–1.51).
Greater remnant cholesterol variability (assessed by SD) was linked to higher CVD risk, with HR 1.07 (1.00-1.15) and highest quartile showing HR 1.31 (1.04-1.65); p-trend=0.029.

Study Design

Type

Cohort (n=5,805)

Structured PICO

Does higher cumulative exposure and variability of remnant cholesterol increase the risk of incident cardiovascular disease in adults?

Population

5,805 adults aged ≥30 years from a community-based cohort, followed for a median of 10.1 years to assess the impact of cumulative remnant cholesterol exposure on cardiovascular disease.

Exposure

Higher cumulative remnant cholesterol (RC) exposure and RC variability

Comparator

Lower cumulative remnant cholesterol (RC) exposure and RC variability (e.g., lowest quartile)

Outcome

Incident cardiovascular disease (CVD), defined as a composite of coronary heart disease (CHD) and strokecomposite

Main Result

Hazard Ratio: 1.27 (95% CI 1.08–1.51)

Cite This Study

Abdi et al. (2026) conducted a cohort in Incident cardiovascular disease (CVD) (n=5,805). Cumulative remnant cholesterol (RC) exposure and RC variability vs. Lower cumulative RC exposure and variability was evaluated on Cardiovascular disease (CVD), defined as a composite of coronary heart disease (CHD) and stroke (HR 1.27, 95% CI 1.08-1.51). Higher cumulative remnant cholesterol burden was independently associated with an increased risk of incident cardiovascular disease (HR 1.27; 95% CI 1.08-1.51).

synapsesocial.com/papers/6a2cf776faef96ed7f058aae https://doi.org/10.1093/eurjpc/zwag249.252

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Cumulative exposure and variability of remnant cholesterol and the risk of cardiovascular disease: two decades of follow-up in a prospective community-based cohort

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Cumulative exposure and variability of remnant cholesterol and the risk of cardiovascular disease: two decades of follow-up in a prospective community-based cohort

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider