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June 13, 2026Journal of sickle cell disease.Open Access

Biomarker Profiles in Distinct Clinical Subphenotypes of Sickle Cell Disease: An Explorative Study

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Authors

VHVera HovingRadboud University NijmegenMBMiranda van BerkelRadboud University NijmegenADAlbertine E. DonkerRadboud University Nijmegen

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Implication

Explorative study evaluates biomarkers in sickle cell disease, identifying subphenotype differences and implications.

Key Points

  • The aim is to evaluate biomarkers related to renal function in different subphenotypes of sickle cell disease.
  • Monocenter exploratory pilot study with 25 patients (12 analyzed) from Radboud Iron Biobank.
  • Patients categorized into hemolysis-dominant and vaso-occlusion–dominant subphenotypes.
  • Quantification of biomarkers using nephelometry, ELISA, and clinical assays, and correlation analyses conducted.
  • Microalbuminuria found in five adults, mostly in hemolysis-dominant subgroup.
  • No macroalbuminuria cases reported; other biomarkers were within reference intervals.
  • Correlation analysis revealed a hemolysis-associated cluster with strong associations to indicators like sFLT-1.

Cite This Study

Hoving et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf776faef96ed7f058bb4https://doi.org/10.1093/jscdis/yoag028
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